Subdural hematoma decompression model: A model of traumatic brain injury with ischemic-reperfusional pathophysiology: A review of the literature

Publication date: 15 March 2018
Source:Behavioural Brain Research, Volume 340
Author(s): Shoji Yokobori, Ryuta Nakae, Hiroyuki Yokota, Markus S. Spurlock, Stefania Mondello, Shyam Gajavelli, Ross M. Bullock
The prognosis for patients with traumatic brain injury (TBI) with subdural hematoma (SDH) remains poor. In accordance with an increasing elderly population, the incidence of geriatric TBI with SDH is rising.An important contributor to the neurological injury associated with SDH is the ischemic damage which is caused by raised intracranial pressure (ICP) producing impaired cerebral perfusion. To control intracranial hypertension, the current management consists of hematoma evacuation with or without decompressive craniotomy. This removal of the SDH results in the immediate reversal of global ischemia accompanied by an abrupt reduction of mass lesion and an ensuing reperfusion injury. Experimental models can play a critical role in improving our understanding of the underlying pathophysiology and in exploring potential treatments for patients with SDH.In this review, we describe the epidemiology, pathophysiology and clinical background of SDH.



http://ift.tt/2C4LK49