Vaccine development targeting lipopolysaccharide structure modification

Publication date: Available online 9 December 2017
Source:Microbes and Infection
Author(s): Yun Zhao, Vilma Arce-Gorvel, Raquel Conde-Álvarez, Ignacio Moriyon, Jean-Pierre Gorvel
Vaccines are one of the most important methods for preventing infectious disease. Structural modification of lipopolysaccharide (LPS) provides a strategy for the development of live attenuated vaccines, either by altering the immunogenicity or by attenuating virulence of the bacteria. This review summarizes various approaches that utilize LPS mutants as whole-cell vaccines.



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