Determination of Fetal Rhesus D Status from Maternal Plasma of Rhesus Negative Women [Internet].

Approximately 15 percent of Norwegian women are Rhesus D (RhD)-negative. During pregnancy and birth, there is a danger that these women produce antibodies against fetal blood cells (alloimmunization), if the fetus is RhD-positive. These antibodies may cross the placenta and cause hemolytic disease of the fetus, which may become life threatening. Today, all RhD-negative pregnant women are closely followed-up during pregnancy, and the newborns are routinely tested for RhD-type at birth. Upon detection of an RhD-positive child, the mother will get anti-D prophylaxis within 72 hours after birth to prevent the formation of anti-D antibodies that may cause problems in subsequent pregnancies.

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