Notching a New Pathway in Vascular Flow Sensing

Publication date: Available online 2 January 2018
Source:Trends in Cell Biology
Author(s): Anne K. Lagendijk, Alpha S. Yap, Benjamin M. Hogan
Vascular barrier function is controlled at cell–cell junctions in response to blood flow, but how vascular endothelial cells sense and respond to flow remains to be understood. A recent study describes a flow-sensing pathway involving non-canonical Notch and cadherin signaling that sheds new light on mechanisms controlling the endothelial barrier.



http://ift.tt/2CB0vwK