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Τετάρτη 31 Ιανουαρίου 2018

Scholar : Xenobiotica, Volume 48, Issue 4, April 2018 is now available online on Taylor & Francis Online

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Xenobiotica, Volume 48, Issue 4, April 2018 is now available online on Taylor & Francis Online.



This new issue contains the following articles:

General Xenobiochemistry

Delayed O-methylation of l-DOPA in MB-COMT-deficient mice after oral administration of l-DOPA and carbidopa
Anne Tammimäki, Anu Aonurm-Helm & Pekka T. Männistö
Pages: 325-331 | DOI: 10.1080/00498254.2017.1315781


Metabolism studies on hydroxygenkwanin and genkwanin in human liver microsomes by UHPLC-Q-TOF-MS
Lin Yuan, Caijuan Liang, Xinpeng Diao, Xiaoye Cheng, Man Liao & Lantong Zhang
Pages: 332-341 | DOI: 10.1080/00498254.2017.1319991


Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines
Shotaro Uehara, Yukako Yuki, Yasuhiro Uno, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki
Pages: 342-347 | DOI: 10.1080/00498254.2017.1321811


A strategy for early-risk predictions of clinical drug–drug interactions involving the GastroPlusTM DDI module for time-dependent CYP inhibitors
Anna-Karin Sohlenius-Sternbeck, Gabrielle Meyerson, Ann-Louise Hagbjörk, Sanja Juric & Ylva Terelius
Pages: 348-356 | DOI: 10.1080/00498254.2017.1323136


Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes
Li Wang, Xiaodan Hong, Zhihong Yao, Yi Dai, Guoping Zhao, Zifei Qin, Baojian Wu, Frank J. Gonzalez & Xinsheng Yao
Pages: 357-367 | DOI: 10.1080/00498254.2017.1323139


Establishment and assessment of a novel in vitro bio-PK/PD system in predicting the in vivo pharmacokinetics and pharmacodynamics of cyclophosphamide
Shanshan Tong, Hong Sun, Caifu Xue, Hanmei Chen, Jing Liu, Huiying Yang, Ning Zhou, Xiaoqiang Xiang & Weimin Cai
Pages: 368-375 | DOI: 10.1080/00498254.2017.1330576


Clinical Pharmacokinetics and Metabolism

Pharmacodynamic properties and bioequivalence of dalteparin sodium subcutaneous injection in healthy Chinese male subjects
Lijin Yu, Xin Guo, Sujie Jia, Yuanyuan Xiang, Zhigang Ding & Ren Guo
Pages: 376-381 | DOI: 10.1080/00498254.2017.1316021


Disposition and metabolism of [14C]-galunisertib, a TGF-βRI kinase/ALK5 inhibitor, following oral administration in healthy subjects and mechanistic prediction of the effect of itraconazole on galunisertib pharmacokinetics
Kenneth C. Cassidy, Ivelina Gueorguieva, Colin Miles, Jessica Rehmel, Ping Yi & William J. Ehlhardt
Pages: 382-399 | DOI: 10.1080/00498254.2017.1323137


Animal Pharmacokinetics and Metabolism

The effect of fenofibric acid on the pharmacokinetics and pharmacodynamics of warfarin in rats
Chaorui Guo, Siqi Xue, Xiufen Zheng, Yang Lu, Di Zhao, Xijing Chen & Ning Li
Pages: 400-406 | DOI: 10.1080/00498254.2017.1306760


Influence of grapefruit juice on pharmacokinetics of triptolide in rats grapefruit juice on the effects of triptolide
Yuzhen Jia, Jie Liu & Jisen Xu
Pages: 407-411 | DOI: 10.1080/00498254.2017.1313470


Study on the pharmacokinetics of deoxyschizandrin and schizandrin in combination with epigallocatechin gallate, a component of green tea, in rats
Yan Liu, Dong Zhang, Yingli Wang, Wenjuan Zhang & Xiaohong Liu
Pages: 412-421 | DOI: 10.1080/00498254.2017.1326187


Topics in Xenobiochemistry

Stereoselective and nonstereoselective pharmacokinetics of rabeprazole – an overview
Ranjeet Prasad Dash, Rana Rais & Nuggehally R. Srinivas
Pages: 422-432 | DOI: 10.1080/00498254.2017.1307470


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