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Πέμπτη 4 Ιανουαρίου 2018

Turning up the Heat with Therapeutic Epigenome Editing

Publication date: 4 January 2018
Source:Cell Stem Cell, Volume 22, Issue 1
Author(s): Alexandra Zezulin, Kiran Musunuru
CRISPR-Cas9 has been touted for therapeutic genome editing, but limitations include inefficient correction of disease-causing mutations and off-target mutagenesis. In the latest issue of Cell, Liao et al. (2017) show that a modified version of CRISPR-Cas9 can target and activate key therapeutic genes in vivo without altering DNA sequence identity.

Teaser

CRISPR-Cas9 has been touted for therapeutic genome editing, but limitations include inefficient correction of disease-causing mutations and off-target mutagenesis. In the latest issue of Cell, Liao et al. show that a modified version of CRISPR-Cas9 can target and activate key therapeutic genes in vivo without altering DNA sequence identity.


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