Data on the TGFβ response of CD4+ T cells in the absence of Eed

Publication date: Available online 17 February 2018
Source:Data in Brief
Author(s): Taku Naito, Sawako Muroi, Ichiro Taniuchi, Motonari Kondo
The data presented here are related to the research article entitled "Loss of Eed leads to lineage instability and increased CD8 expression of mouse CD4⁺ T cells upon TGFβ signaling" [1]. The cited research article investigates the molecular mechanism of CD8α upregulation observed in Eed-deficient (∆Eed) CD4⁺ T cells upon activation in the presence of TGFβ. This data report describes the effect of retinoic acid (RA) and/or interferon-gamma (IFNγ) supplementation on up-regulation of CD8α and Foxp3 in ∆Eed CD4⁺ T cells, the effect of dose or timing of TGFβ treatment on CD4⁺ T cell identity of ∆Eed, adding further information regarding the conditions that induces CD8α, and mRNA expression changes of genes encoding polycomb repressive complex 2 (PRC2) subunits by TGFβ treatment.



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