Pediatric brain tumors: Update of proteome-based studies

Publication date: Available online 19 February 2018
Source:Journal of Proteomics
Author(s): G.T. Tsangaris, A.K. Anagnostopoulos
Pediatric brain tumors (PBTs) are the most common solid malignancies in childhood and continue to pose a serious burden to modern societies. Existing treatments impose debilitating effects on the developing child, highlighting the need for molecularly targeted treatments with reduced toxicity, and the necessity of markers that reliably assess efficacy of, and tumor response to targeted-therapies of PBTs. On this regard advances in technologies of protein identification and quantification, the large-scale, high-throughput investigation of the proteome, as well the newly-emerging field of "proteogenomics" aim to further our knowledge towards understanding the molecular pathophysiology of PBTs. This mini review article updates knowledge produced and published during the last years on PBT research derived from "omics" technologies, mainly involving protein research and proteomics.



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