A Novel Mechanism to Drive Castration-Resistant Prostate Cancer

Publication date: Available online 28 March 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Salma Kaochar, Nicholas Mitsiades
Androgen receptor signaling is critical for prostate adenocarcinoma, even after androgen deprivation therapy. Persistence of intratumoral androgens has been found in castration-resistant prostate cancer and attributed to increased in situ synthesis. Recently, Sharifi and colleagues reported an additional mechanism that can enhance local androgenic exposure: downregulation of an androgen-inactivating enzyme.



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