Early TCR Signaling Sweetens Effector Function through PDHK1

Publication date: Available online 31 March 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Nina Weisshaar, Alaa Madi, Guoliang Cui
T cells rapidly engage glycolysis upon activation. The signaling pathways through which T cell receptor (TCR) activation initiates glycolysis have been a mystery. A long-awaited answer has been provided by Menk et al., who show that pyruvate dehydrogenase kinase 1 (PDHK1) is in the center of signaling events linking TCR activation to glycolysis.



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