Improving thermal control of capillary electrophoresis with mass spectrometry and capacitively coupled contactless conductivity detection by using 3D printed cartridges

Publication date: 1 August 2018
Source:Talanta, Volume 185
Author(s): Kelliton José Mendonça Francisco, Claudimir Lucio do Lago
A 3D-printed cartridge was developed to improve the interface between a capillary electrophoresis instrument and a mass spectrometer. The thermostated airflow from the CE was guided to the entrance of the electrospray source keeping as much as possible the silica capillary in a proper Joule-heating dissipation environment. Hollow 3D-printed walls made of ABS covered by a 0.2 mm thick copper foil on the inner side were used. The cartridge also allows including up to two capacitively coupled contactless conductivity detectors (C⁴Ds). Experiments about the separation of monoethyl carbonate (a thermally unstable species) shows that the peak area obtained with the original cartridge is only 21% of the value obtained with the 3D-printed cartridge, which demonstrates the improvement in heat dissipation.



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