Ετικέτες

Παρασκευή 23 Μαρτίου 2018

Multi-locus transcranial magnetic stimulation—theory and implementation

Publication date: Available online 23 March 2018
Source:Brain Stimulation
Author(s): Lari M. Koponen, Jaakko O. Nieminen, Risto J. Ilmoniemi
BackgroundTranscranial magnetic stimulation (TMS) is a non-invasive brain stimulation method: a magnetic field pulse from a TMS coil can excite neurons in a desired location of the cortex. Conventional TMS coils cause focal stimulation underneath the coil centre; to change the location of the stimulated spot, the coil must be moved over the new target. This physical movement is inherently slow, which limits, for example, feedback-controlled stimulation.ObjectiveTo overcome the limitations of physical TMS coil movement by introducing electronic targeting.MethodsWe propose electronic stimulation targeting using a set of large overlapping coils and introduce a matrix-factorisation-based method to design such sets of coils. We built one such device and demonstrated the electronic stimulation targeting in vivo.ResultsThe demonstrated two-coil transducer allows translating the stimulated spot along a 30-mm line segment in the cortex; with five coils, a target can be selected from within a region of the cortex and stimulated in any direction. Thus, far fewer coils are required by our approach than by previously suggested ones, none of which have resulted in practical devices.ConclusionAlready with two coils, we can adjust the location of the induced electric field maximum along one dimension, which is sufficient to study, for example, the primary motor cortex.



https://ift.tt/2DQZAnv

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Αναζήτηση αυτού του ιστολογίου