The Missed Notch to Bring Down Diabetes

Publication date: Available online 29 March 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Peter Mirtschink, Triantafyllos Chavakis
Notch signaling contributes to maintenance of adult tissue homeostasis and is also involved in disease. A recent study demonstrates that inhibition of Dll4–Notch signaling by anti-Dll4 improves pancreatic islet function and insulin production by multiple complementary mechanisms. Thus, anti-Dll4 represents a therapeutic approach for compromised insulin production in diabetes.



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