A population-based audit of surgical practice and outcomes of oncoplastic breast conservations in Scotland – an analysis of 589 patients

Publication date: Available online 13 April 2018
Source:European Journal of Surgical Oncology
Author(s): Laszlo Romics, E. Jane Macaskill, Teresa Fernandez, Louise Simpson, Elizabeth Morrow, Vassilis Pitsinis, Sian Tovey, Matthew Barber, Yazan Masannat, Sheila Stallard, Eva Weiler-Mithoff, Andrew Malyon, James Mansell, Esther J. Campbell, Julie Doughty, J. Michael Dixon
IntroductionCurrent evidence for oncoplastic breast conservation (OBC) is based on single institutional series. Therefore, we carried out a population-based audit of OBC practice and outcomes in Scotland.MethodsA predefined database of patients treated with OBC was completed retrospectively in all breast units practicing OBC in Scotland.Results589 patients were included from 11 units. Patients were diagnosed between September 2005 and March 2017. High volume units performed a mean of 19.3 OBCs per year vs. low volume units who did 11.1 (p=0.012). 23 different surgical techniques were used. High volume units offered a wider range of techniques (8 – 14) than low volume units (3 – 6) (p=0.004). OBC was carried out as a joint operation involving a breast and a plastic surgeon in 389 patients. Immediate contralateral symmetrisation rate was significantly higher when OBC was performed as a joint operation (70.7% vs. not joint operations: 29.8%; p<0.001). The incomplete excision rate was 10.4% and was significantly higher after surgery for invasive lobular carcinoma (18.9%; p=0.0292), but was significantly lower after neoadjuvant chemotherapy (3%; p=0.031). 9.2% of patients developed major complications requiring hospital admission. Overall the complication rate was significantly lower after neoadjuvant chemotherapy (p=0.035). The 5 year local recurrence rate was 2.7%, which was higher after OBC for DCIS (8.3%;) than invasive ductal cancer (1.6%; p=0.026). 5-year disease-free survival was 91.7%, overall survival was 93.8%, and cancer-specific survival was 96.1%.ConclusionThis study demonstrated that measured outcomes of OBC in a population-based multi-centre setting can be comparable to the outcomes of large volume single centre series.



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