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Τρίτη 10 Απριλίου 2018

EEG-based neurophysiological indicators of hallucinations in Alzheimer's disease: Comparison with dementia with Lewy bodies

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Publication date: July 2018
Source:Neurobiology of Aging, Volume 67
Author(s): Meenakshi Dauwan, Mascha M.J. Linszen, Afina W. Lemstra, Philip Scheltens, Cornelis J. Stam, Iris E. Sommer
We studied neurophysiological indicators of hallucinations in Alzheimer's disease patients with hallucinations (ADhall+), and compared them with nonhallucinating AD (ADhall−) and dementia with Lewy bodies (DLBhall+) patients. Thirty-six matched ADhall+ and 108 ADhall− and 29 DLBhall+ patients were selected from the Amsterdam Dementia Cohort. Electroencephalography (EEG) spectral and functional connectivity (FC) analyses (phase lag index) were performed. Quantitative and visual EEG measures were combined in a random forest algorithm to determine which EEG-based variable(s) play a role in hallucinations. ADhall+ patients showed lower peak frequency (7.26 vs. 7.94 Hz, p < 0.01), α2-and β-power, and α2-FC but higher δ-power compared to ADhall−. ADhall+ showed lower δ-power, higher β-power, and α1-FC than DLBhall+ but did not differ in peak frequency (7.26 vs. 6.95 Hz), θ- or α-power. ADhall+ patients could be differentiated from ADhall− and DLBhall+ with a weighted accuracy of 71% with α1-power and 100% with β-FC, the 2 most differentiating features. In sum, EEG slowing and decrease in α1-and β-band activity form potential neurophysiological indicators of underlying cholinergic deficiency in ADhall+ and DLBhall+.



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