Comparing Therapeutic versus Prophylactic Nipple-Sparing Mastectomy: Does Indication Inform Oncologic and Reconstructive Outcomes?

Background: Initially performed in only prophylactic cases, indications for nipple-sparing mastectomy (NSM) have expanded. Trends and surgical outcomes stratified by NSM indication have not yet been fully examined. Methods: Demographics and outcomes for all NSMs performed from 2006 to 2017 were compared by mastectomy indication. Results: A total of 1212 NSMs were performed: 496 (40.9%) and 716 (59.1%) for therapeutic and prophylactic indications. Follow-up time was similar between both the therapeutic and prophylactic NSM groups (47.35 versus 46.83 months; p=0.7942). Prophylactic NSMs were significantly associated with younger age (p=0.0007), bilateral reconstruction (p

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