MENIN loss as a tissue-specific driver of tumorigenesis

Publication date: 5 July 2018
Source:Molecular and Cellular Endocrinology, Volume 469
Author(s): Janet W.Y. Li, Xianxin Hua, Diane Reidy-Lagunes, Brian R. Untch
The MEN1 gene encodes MENIN, a tumor suppressor that plays a role in multiple cellular processes. Germline and somatic mutations in MEN1 have been identified in hereditary and sporadic tumors of neuroendocrine origins suggesting context-specific functions. In this review, we focus on the development of mutational Men1 in vivo models, the known cellular activities of MENIN and efforts to identify vulnerabilities in tumors with MENIN loss.



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