No association between 5 new GWAS-linked loci in Parkinson's disease and multiple system atrophy in a Chinese population

Publication date: July 2018
Source:Neurobiology of Aging, Volume 67
Author(s): Yongping Chen, Bei Cao, Xiaojing Gu, Ruwei Ou, Qianqian Wei, Hui Liu, Lingyu Zhang, Xiaoqin Yuan, Wei Song, Bi Zhao, Ying Wu, Lixing Yuan, Jingqiu Cheng, Huifang Shang
Recently, 17 new Parkinson's disease (PD) risk loci were identified in a genome-wide association studies meta-analysis in Caucasians; however, their association with PD in Chinese patients is largely unknown. Therefore, we performed a replication study of 5 of the most commonly identified candidate variants, including SORBS3 rs2280104, SCN3A rs353116, TOX3 rs4784227, GLAC rs8005172, and ZNF184 rs9468199, in a large sample of patients with PD (1506) and multiple system atrophy (MSA, 496) in a Chinese population. These 5 variants were found to not be associated with PD and MSA in the Chinese population. Our results suggest that these variants are not risk factors for PD or MSA in the Chinese population.



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