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Δευτέρα 21 Μαΐου 2018

Plasma Membrane Localization of Apoptotic Caspases for Non-apoptotic Functions

Publication date: 21 May 2018
Source:Developmental Cell, Volume 45, Issue 4
Author(s): Alla Amcheslavsky, Shiuan Wang, Caitlin E. Fogarty, Jillian L. Lindblad, Yun Fan, Andreas Bergmann
Caspases are best characterized for their function in apoptosis. However, they also have non-apoptotic functions such as apoptosis-induced proliferation (AiP), where caspases release mitogens for compensatory proliferation independently of their apoptotic role. Here, we report that the unconventional myosin, Myo1D, which is known for its involvement in left/right development, is an important mediator of AiP in Drosophila. Mechanistically, Myo1D translocates the initiator caspase Dronc to the basal side of the plasma membrane of epithelial cells where Dronc promotes the activation of the NADPH-oxidase Duox for reactive oxygen species generation and AiP in a non-apoptotic manner. We propose that the basal side of the plasma membrane constitutes a non-apoptotic compartment for caspases. Finally, Myo1D promotes tumor growth and invasiveness of the neoplastic scrib RasV12 model. Together, we identified a new function of Myo1D for AiP and tumorigenesis, and reveal a mechanism by which cells sequester apoptotic caspases in a non-apoptotic compartment at the plasma membrane.

Graphical abstract

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Teaser

Amcheslavsky et al. provide a mechanism by which cells activate caspases without the detrimental consequences of apoptosis. In Drosophila, the unconventional myosin Myo1D localizes the initiator caspase Dronc to the basal side of the plasma membrane of epithelial cells. Here, Dronc can fulfill non-apoptotic functions such as apoptosis-induced proliferation.


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