The Krebs Uric Acid Cycle: A Forgotten Krebs Cycle

Publication date: Available online 26 May 2018
Source:Trends in Biochemical Sciences
Author(s): Jack G. Salway
Hans Kornberg wrote a paper entitled 'Krebs and his trinity of cycles' commenting that every school biology student knows of the Krebs cycle, but few know that Krebs discovered two other cycles. These are (i) the ornithine cycle (urea cycle), (ii) the citric acid cycle (tricarboxylic acid or TCA cycle), and (iii) the glyoxylate cycle that was described by Krebs and Kornberg. Ironically, Kornberg, codiscoverer of the 'glyoxylate cycle', overlooked a fourth Krebs cycle – (iv) the uric acid cycle.



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