A Reversible Epigenetic Link between Obesity and Cancer Risk

Publication date: Available online 5 June 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Scott J. Bultman
In a recent Cell Reports article, Li et al. report that obesity is associated with altered fatty acid metabolism and DNA methylation in the colonic epithelium, which precede a tumor-prone gene-expression profile. Interestingly, obesity-associated methylation and transcriptome changes were reversed by weight loss, and the duration of weight loss correlated with the extent of restored gene expression. These findings have implications that are encouraging for weight loss and cancer prevention.



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