Application of sesquiterpene lactone: A new promising way for cancer therapy based on anticancer activity

Publication date: October 2018
Source:Biomedicine & Pharmacotherapy, Volume 106
Author(s): Ghader babaei, Azadeh Aliarab, Sina Abroon, Yusof Rasmi, Shiva Gholizadeh- Ghaleh Aziz
Cancer is one of the most dangerous diseases that are rapidly increasing globally. After heart disease, it is the second leading cause of death, accounting for seven million deaths each year. Chemotherapy is the use of cytotoxic drugs on cancer cells. But the use of common chemotherapy drugs poses a problem due their high side effects and low efficacy. As a result, efforts are on to find new potent compounds with low side effects. The compounds extracted from plants have been studied in this regard due to their prevalence. Sesquiterpene lactones are a group of natural compounds that were first detected in Asteraceae dark plants. These compounds exercise their effects by reacting with functional groups available on proteins and enzymes, especially the thiol group. Owing to the high side effects as an antitumor synthetic drugs, efforts are being made to find drugs with high efficiency and low side effects. Their high structural ranges have attracted the attention of many researchers as a potential source of new anticancer drugs.



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