Database Selection and Heterogeneity—More Details, More Credibility

To the Editor We read with great interest the article by Barroso-Sousa et al. The analysis includes 38 randomized clinical trials comprising 7551 patients and suggests that patients receiving combination therapy are at increased risk of thyroid dysfunction and hypophysitis. In general, it is an excellent and well-designed meta-analysis that provides more precise data on the incidence of endocrine dysfunction among patients receiving immune checkpoint inhibitor regimens. However, we would like to address some potential questions regarding the content of this article.

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