Reply to Hua Liu, HaiCun Shi and PingLei Pan: Coordinate based meta-analyses in a medium sized literature: considerations, limitations and road ahead

We thank Liu and colleagues for their interest in and thoughtful comments on our neuroimaging meta-analysis on insomnia disorder (1). In their commentary, the authors highlight the conceptual and technical diversity among current neuroimaging approaches, including those that were integrated in our recent analysis. We completely concur with their summary on these differences, as indeed different modalities and analysis methods reveal different neurobiological features (2, 3). Therefore, we would like to focus on what we perceive as the critical question arising from this commentary, namely whether the findings obtained by the different methods can be combined in a useful and interpretable way by meta-analyses.

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