Primary Localized Cutaneous Amyloidosis Affecting Female Individuals of a Pakistani Pedigree

Abstract: Primary localized cutaneous amyloidosis is a group of rare conditions where amyloid deposition is limited to the skin without systemic manifestations. Most cases are sporadic; however, mutations in the oncostatin M receptor (OSMR) and interleukin-31 receptor A (IL31RA) genes can cause a familial form of the condition in up to 10% of cases. Here, we describe a family in which 8 female individuals are affected by either macular amyloidosis or amyloidosis cutis dyschromica. To the best of our knowledge, a sex-specific expression or the coexistence of 2 different phenotypes of primary localized cutaneous amyloidosis in 1 pedigree has not yet been reported. Correspondence: Bevin Bhoyrul, Department of Dermatology, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, United Kingdom (e-mail: bevin.bhoyrul@nhs.net). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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