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Σάββατο 22 Δεκεμβρίου 2018

Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females

Summary

Objective

Research findings on the relationship between serum androgens and adipose tissue in older females are inconsistent. We aimed to clarify the relationship using state‐of‐the art techniques to evaluate associations between body fat distribution and plasma testosterone (T) levels in older postmenopausal women.

Design

Observational, cross‐sectional study of healthy, community dwelling postmenopausal women.

Patients and Measurements

Postmenopausal women, (60‐80 years old) were included in this study. Overall body composition was evaluated by dual‐energy x‐ray absorptiometry. Abdominal and thigh fat depots were measured by magnetic resonance imaging. Circulating T concentrations by liquid chromatography‐tandem mass spectrometry.

Results

Thirty‐five women (66.6 ± 0.8 years) participated in this study. T levels were positively associated with clinical proxy measure of adiposity including weight (ρ=0.39), BMI (ρ=0.43) and waist circumference (ρ=0.39) (all p<0.05). Fat mass and percent body fat were correlated with T levels (ρ=0.42 and 0.38 respectively, both p<0.05). T correlated with overall and superficial abdominal fat (ρ=0.34 and 0.37 respectively, both p<0.05) but not with visceral adipose tissue. T increased with greater thigh fat (ρ=0.49, p<0.05) in both superficial and deep depots (ρ=0.50 and 0.35 respectively, both p<0.05).

Conclusion

Our results suggest that postmenopausal women with higher circulating T levels have both higher regional and overall body adiposity. These findings underscore the sexual dimorphism in the relationship between serum androgen levels and adiposity.

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