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Δευτέρα 17 Ιουνίου 2019

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


Drug Safety : Drug safety evaluation of naltrexone/bupropion for the treatment of obesity , Benefits versus risk profile of buparlisib for the treatment of breast cancer , Histone deacetylase inhibitors for the treatment of myeloma, Muscle and statins, Glucocorticoid-related adverse events in patients with rheumatoid arthritis, Safety of epidural drugs, Safety and tolerability of injectable lipid-lowering drugs, Occurrence of hepatocellular carcinoma after direct-acting antiviral therapy for hepatitis C virus infection, Disproportionality analysis of bullous pemphigoid adverse events with PD-1 inhibitors in the FDA adverse event reporting system,
 Update on drug safety evaluation of naltrexone/bupropion for the    treatment of obesity    Nicholas T. Bello    Pages: 549-552    DOI: 10.1080/14740338.2019.1618268    https://www.tandfonline.com/action/doSecureKeyLogin?uuid=d8594a82-ce8d-4e6c-8a1f-0da062c12f34&dateTime=201906240338&key=Y0T740bBERH2A2OfLiazdrjW%2FSBOVptff8I2XzU7I0M%3D&uri=https%3A%2F%2Fwww.tandfonline.com%2Fdoi%2Fabs%2F10.1080%2F14740338.2019.1618268%3Fai%3D1pmh6%26ui%3D843fx%26af%3DT    Benefits versus risk profile...
Αλέξανδρος Γ. Σφακιανάκης
now
Treatment with selenium-enriched Saccharomyces cerevisiae UFMG A-905 partially ameliorates mucositis...
Treatment with selenium-enriched Saccharomyces cerevisiae UFMG A-905 partially ameliorates mucositis induced by 5-fluorouracil in miceAbstractPurposeGastrointestinal mucositis is a major problem associated with cancer therapy. To minimize these deleterious effects, simultaneous administration of antioxidant components, such as selenium, can be considered. There is a growing interest in the use of yeasts because they are able to convert inorganic selenium into selenomethionine. In the present study,...
Αλέξανδρος Γ. Σφακιανάκης
6m
Orally administered salecan ameliorates methotrexate-induced intestinal mucositis in mice AbstractPurpose...
Orally administered salecan ameliorates methotrexate-induced intestinal mucositis in miceAbstractPurposeMethotrexate (MTX) is a widely used cancer chemotherapy agent. The efficacy of MTX is often limited by serious side effects, such as intestinal mucositis. The aim of this study was to evaluate the protective effect of water-soluble β-glucan salecan on MTX-induced intestinal toxicity in mice.MethodsIntestinal mucositis was induced in C57BL/6 mice by intraperitoneal injection of MTX for two consecutive...
Αλέξανδρος Γ. Σφακιανάκης
6m
Olanzapine-containing antiemetic therapy for the prevention of carboplatin-induced nausea and vomiting...
Olanzapine-containing antiemetic therapy for the prevention of carboplatin-induced nausea and vomitingAbstractPurposeThere remains an unmet clinical need for the control of chemotherapy-induced nausea and vomiting (CINV), particularly in the prevention of nausea and the delayed phase control. We evaluated the efficacy and safety of antiemetic therapy with olanzapine, a neurokinin-1 receptor antagonist, a 5-hydroxytryptamine-3 (5-HT3) receptor antagonist and dexamethasone in patients receiving carboplatin-containing...
Αλέξανδρος Γ. Σφακιανάκης
7m
Development of cutaneous squamous cell carcinoma after prolonged exposure to pegylated liposomal doxorubicin...
Development of cutaneous squamous cell carcinoma after prolonged exposure to pegylated liposomal doxorubicin and hand–foot syndrome: a newly recognized toxicityAbstractPegylated liposomal doxorubicin (PLD) can be administered for prolonged periods with minimal toxicity. The risk of cutaneous squamous cell carcinoma (SCC) with this therapy has not been reported. We describe cutaneous SCC of the plantar foot in two patients exposed to high doses of PLD. A 50-year-old man with angiosarcoma received...
Αλέξανδρος Γ. Σφακιανάκης
8m
Cancer Chemotherapy and Pharmacology
Efficacy of immunotherapy, gut microbiota and impact of antibiotic use: are there confounding factors?Qualitative and quantitative variations in liver function thresholds among clinical trials in cancer: a need for harmonizationAbstractPurposeThe liver is critically involved in drug metabolism pathways and the potential for hepatic toxicity is significant with specific cancer therapeutics. Variations in the definition of liver function thresholds that may generate heterogeneity of toxicity and efficacy...
Αλέξανδρος Γ. Σφακιανάκης
8m
Spine
Diabetes mellitus as a risk factor for intervertebral disc degeneration: a critical reviewAbstractPurposeTo examine to what extent diabetes mellitus (DM) is implicated as a distinct mechanism in intervertebral disc degeneration (IVDD).MethodsThe published clinical and laboratory data relevant to this matter are critically reviewed. A total of 12 clinical studies evaluate the association between DM and degenerative changes such as IVDD, spinal stenosis (SS) and IVD herniation. A total of 34 laboratory...
Αλέξανδρος Γ. Σφακιανάκης
9m
Brain Structure and Function
Mitral cell development in the olfactory bulb of sharks: evidences of a conserved pattern of glutamatergic neurogenesisAbstractIn mammals, the development of the olfactory bulb (OB) relies in part on the expression of transcription factors involved in the specifications/differentiation of glutamatergic cells. In a previous study from our group, a high molecular similarity was reported between mammals and cartilaginous fishes regarding the neurogenic mechanisms underlying the development of glutamatergic...
Αλέξανδρος Γ. Σφακιανάκης
12m
Gynäkologische Endokrinologie
Neues aus der Schweizerischen Menopausengesellschaft / SMGÉditorialEditorialAbnorme uterine Blutungen in der Peri- und PostmenopauseZusammenfassungBlutungsstörungen in der Peri- und Postmenopause gehören zu den häufigsten Beschwerdebildern in der gynäkologischen Praxis. Sie machen ca. 70 % aller Konsultationen in dieser Altersgruppe aus. Meist sind hormonelle Dysbalancen infolge der nachlassenden ovariellen Aktivität Ursache der abnormen uterinen Blutungen (AUB) in der Perimenopause. Im Rahmen der...
Αλέξανδρος Γ. Σφακιανάκης
13m
Cardiovascular Intervention and Therapeutics
Transcatheter closure of an aorto–right ventricular fistula after TAVRPull-down maneuver of stent graft for abdominal aortic aneurysm with accessory renal arteriesPercutaneous closure of patent foramen ovale for paradoxical embolism in acute limb ischemiaLeft bundle branch block during antegrade balloon aortic valvuloplasty caused by stiff-wire loop stressThe brand-new Inoue balloon for retrograde approach: first experience in JapanTranscatheter aortic valve implantation using Evolut R in quadricuspid...
Αλέξανδρος Γ. Σφακιανάκης
14m
Der Ophthalmologe
Exzision und tektonische Deckung eines vaskulären Leiomyoms des Ziliarkörpers mit großem anteriorem Staphylom mittels SklerapatchZusammenfassungBenigne Tumoren des Ziliarkörpers sind selten und verleiten im Klinikalltag zu Verwechslungen mit Uveamelanomen. Die klinischen Befunde erlauben nur selten eine sichere Differenzierung, sodass es häufig primär zur Exzision kommt. Wir berichten über den Fall eines Patienten mit benignem Ziliarkörpertumor, welcher im Verlauf über insgesamt 13 Jahre beobachtet...
Αλέξανδρος Γ. Σφακιανάκης
17m
Der Anaesthesist
Perioperative kardiovaskuläre Morbidität und Letalität bei nichtherzchirurgischen EingriffenZusammenfassungDie perioperative Morbidität und Letalität haben sich in den letzten Jahrzehnten u. a. durch fortschrittliche Operationstechniken, umfangreichere Überwachungsmöglichkeiten und effektivere perioperative Medizin deutlich reduziert. Jedoch besteht insbesondere für kardiovaskulär vorerkrankte Patienten weiterhin ein nichtunerhebliches perioperatives Morbiditäts- und Letalitätsrisiko. Diese vulnerable...
Αλέξανδρος Γ. Σφακιανάκης
22m
Minds and Machines
Reply to "Prayer-Bots and Religious Worship on Twitter: A Call for a Wider Research Agenda Islamic"Three Ethical Challenges of Applications of Artificial Intelligence in CybersecurityDelegating Religious Practices to Autonomous Machines, A Reply to "Prayer-Bots and Religious Worship on Twitter: A Call for a Wider Research Agenda"Triviality Arguments ReconsideredAbstractOpponents of the computational theory of mind (CTM) have held that the theory is devoid of explanatory content, since whatever computational...
Αλέξανδρος Γ. Σφακιανάκης
24m
Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic...
Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinicCurrently, immune checkpoint blockade (ICB) therapy has increased the overall survival (OS) rates of patients with advanced melanoma, non-small-cell lung cancer (NSCLC), urothelial cancer (UC), renal cell carcinoma (RCC), and other cancer types [1–8].
Αλέξανδρος Γ. Σφακιανάκης
31m
Immune biomarkers of response to immune-checkpoint inhibitors in head and neck squamous cell carcinoma...
Immune biomarkers of response to immune-checkpoint inhibitors in head and neck squamous cell carcinomaImmune-checkpoint inhibitors (ICI) targeting cytotoxic T-lymphocyte antigen 4 and programmed cell death protein-1 (PD-1) and its ligands, programmed death ligand-1 (PD-L1)/2, have shown a significant and consistent benefit in survival when compared with standard therapies in prospective randomized clinical trials, leading to their regulatory approval in multiple tumor types [1–5].
Αλέξανδρος Γ. Σφακιανάκης
32m
Deficiencies in health-related quality-of-life assessment and reporting: a systematic review of oncology...
Deficiencies in health-related quality-of-life assessment and reporting: a systematic review of oncology randomized phase III trials published between 2012 and 2016From both a regulatory and a clinical point of view, the main goal of any anticancer treatment is to allow patients to live longer and/or to live better [1]. Although appropriate end points in randomized controlled trials (RCTs) depend on the clinical setting, experimental treatments should ideally demonstrate a tangible clinical benefit...
Αλέξανδρος Γ. Σφακιανάκης
32m
Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors...
Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumorsDrug development in oncology is shifting from targeting intrinsic properties of cancer cells to the tumor microenvironmental and the immune system of the host. Boosting T-cell memory may lead to more durable anticancer responses than seen with conventional anticancer therapy [1]. Endogenous anticancer response can be enhanced by blocking inhibitory checkpoint molecules.
Αλέξανδρος Γ. Σφακιανάκης
32m
Cerebrospinal fluid cell-free tumour DNA as a liquid biopsy for primary brain tumours and central nervous...
Cerebrospinal fluid cell-free tumour DNA as a liquid biopsy for primary brain tumours and central nervous system metastasesGenomic characterisation of tumour tissue has been established as crucial for state-of-the-art diagnostic and therapeutic approaches to cancer. However, characterisation of cancer is challenged by constitutive and evolving intra-tumour and inter-lesion heterogeneity, which requires thorough and continuous analysis of genomic complexity over time.
Αλέξανδρος Γ. Σφακιανάκης
33m
Melanoma and Skin Cancer Awareness Month Read one of Annals of Oncology's most read articles on the...
Melanoma and Skin Cancer Awareness MonthRead one of Annals of Oncology's most read articles on the subject of melanoma: Man against machine: diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists by H A Haenssle, et al.Read now
Αλέξανδρος Γ. Σφακιανάκης
33m
Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL): a...
Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL): a multicentre, open-label, randomised, controlled phase II trialAlthough substantial progress has been achieved in the management of unresectable and metastatic melanoma, it remains a fatal disease. Impressive anticancer activity has been shown by kinase inhibitors, which target aberrant signalling in the 50% of melanomas with BRAF mutations, and antibodies that bind to the immune checkpoints cytotoxic...
Αλέξανδρος Γ. Σφακιανάκης
33m
REVERCE: a randomized phase II study of regorafenib followed by cetuximab versus the reverse sequence...
REVERCE: a randomized phase II study of regorafenib followed by cetuximab versus the reverse sequence for previously treated metastatic colorectal cancer patientsThe treatment of metastatic colorectal cancer (mCRC) has evolved considerably over the past two decades [1, 2]. Two randomized trials in the first-line setting compared chemotherapy with bevacizumab versus anti-epidermal growth factor (EGFR) monoclonal antibodies for patients with wild-type (WT) KRAS exon 2 mCRC [3, 4].
Αλέξανδρος Γ. Σφακιανάκης
34m
Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation...
Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation studyOncogenic NTRK gene fusions encoding constitutively activated TRK tyrosine kinases occur across a wide range of tumours. Larotrectinib is a first-in-class potent and highly selective inhibitor of TRK kinases. In this first-in-human, phase I dose-escalation study, we showed that larotrectinib was well tolerated and provided consistent and durable antitumour activity in adults with TRK fusion...
Αλέξανδρος Γ. Σφακιανάκης
34m
OPTIMA: a phase II dose and volume de-escalation trial for human papillomavirus-positive oropharyngeal...
OPTIMA: a phase II dose and volume de-escalation trial for human papillomavirus-positive oropharyngeal cancerHuman papillomavirus (HPV)+ oropharyngeal squamous cell carcinoma (OPSCC) is a distinct entity with RTOG 0129 reporting long-term overall survival (OS) of 71% for stage III/IV HPV+ disease compared with 30% for HPV-negative tumors after concurrent chemoradiotherapy (CRT) [1]. Since full-dose CRT imparts considerable toxicity, [2, 3] de-escalation for favorable HPV+ OPSCC represents a rational...
Αλέξανδρος Γ. Σφακιανάκης
34m
Anti-EGFR-resistant clones decay exponentially after progression: implications for anti-EGFR re-challenge...
Anti-EGFR-resistant clones decay exponentially after progression: implications for anti-EGFR re-challengePatients with KRAS/NRAS (RAS) wild-type metastatic colorectal cancer (mCRC) have improved survival when treated with anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibodies. However, these agents do not benefit patients with oncogenic RAS mutations [1–4]. Though less common, alterations in BRAF/HER2 and MAP2K1 (MEK) are additional biomarkers of primary resistance to anti-EGFR [5–7].
Αλέξανδρος Γ. Σφακιανάκης
35m
Prognostic implications of residual disease tumor-infiltrating lymphocytes and residual cancer burden...
Prognostic implications of residual disease tumor-infiltrating lymphocytes and residual cancer burden in triple-negative breast cancer patients after neoadjuvant chemotherapyNeoadjuvant chemotherapy (NAC) is a commonly utilized strategy for the treatment of early-stage triple-negative breast cancer (TNBC). A major advantage of this strategy is the ability to observe the tumor response to chemotherapy. Pathologic complete response (pCR) is a well-established end point of NAC clinical trials, and serves...
Αλέξανδρος Γ. Σφακιανάκης
35m
Long-course preoperative chemoradiation vs. 5 x 5 Gy and consolidation chemotherapy for clinical T4...
Long-course preoperative chemoradiation vs. 5 x 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: Long-term results of the randomized Polish II studyB Ciseł  L Pietrzak  W Michalski  L Wyrwicz  A Rutkowski E Kosakowska  A Cencelewicz  M Spałek  W Polkowski  M Jankiewicz ... Show moreAnnals of Oncology, mdz186, https://doi.org/10.1093/annonc/mdz186Published: 13 June 2019CitePermissions Icon Permissions ShareAbstractBackgroundThis trial evaluated whether preoperative...
Αλέξανδρος Γ. Σφακιανάκης
37m
Medical Primatology
Early reversal of ketamine/dexmedetomidine chemical immobilization by atipamezole in golden‐headed lion tamarins (Leontopithecus chrysomelas)Journal of Medical Primatology, EarlyView. Detection of hepatitis E virus antibodies among Cercopithecidae and Hominidae monkeys in CameroonJournal of Medical Primatology, EarlyView. Image correction for diffusion tensor imaging of Rhesus monkey thoracic spinal cordJournal of Medical Primatology, EarlyView. Spontaneous pulmonary adenocarcinoma and subcutaneous...
Αλέξανδρος Γ. Σφακιανάκης
1h
Automatic assessment of glioma burden: A deep learning algorithm for fully automated volumetric and...
Automatic assessment of glioma burden: A deep learning algorithm for fully automated volumetric and bi-dimensional measurementKen Chang, MSE  Andrew L Beers, BA  Harrison X Bai, MD James M Brown, PhD  K Ina Ly, MD  Xuejun Li, MD Joeky T Senders, BS  Vasileios K Kavouridis, MD Alessandro Boaro, MD  Chang Su, BSE  ... Show moreNeuro-Oncology, noz106, https://doi.org/10.1093/neuonc/noz106Published: 13 June 2019  Article history pdfPDF  Split View CitePermissions Icon Permissions ShareAbstractBackgroundLongitudinal...
Αλέξανδρος Γ. Σφακιανάκης
1h
Nutrition
Maternal betaine protects rat offspring from glucocorticoid-induced activation of lipolytic genes in adipose tissue through modification of DNA methylationAbstractPurposeExcessive exposure of glucocorticoids activates adipose lipolysis, increases circulating free fatty acids, and contributes to ectopic lipid deposition in liver and skeletal muscle. Our previous study demonstrated that maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation in rat offspring. However,...
Αλέξανδρος Γ. Σφακιανάκης
1h
Current Treatments and New Developments in the Management of Glucocorticoid-induced Osteoporosis Abstract...
Current Treatments and New Developments in the Management of Glucocorticoid-induced OsteoporosisAbstractGlucocorticoids (GCs) are often used for improvement of quality of life, particularly in the elderly, but long-term GC use may cause harm; bone loss and fractures are among the most devastating side effects. Fracture risk is particularly high in patients with a severe underlying disease with an urgent need for treatment with high-dose GCs. Moreover, it is important to realize that these patients...
Αλέξανδρος Γ. Σφακιανάκης
1h
Drugs
Current Treatments and New Developments in the Management of Glucocorticoid-induced OsteoporosisAbstractGlucocorticoids (GCs) are often used for improvement of quality of life, particularly in the elderly, but long-term GC use may cause harm; bone loss and fractures are among the most devastating side effects. Fracture risk is particularly high in patients with a severe underlying disease with an urgent need for treatment with high-dose GCs. Moreover, it is important to realize that these patients...
Αλέξανδρος Γ. Σφακιανάκης
1h
A new anti- Helicobacter pylori juglone from Reynoutria japonica Abstract A 70% ethanol extract from...
A new anti- Helicobacter pylori juglone from Reynoutria japonicaAbstractA 70% ethanol extract from the root portion of Reynoutria japonica afforded one new and three known juglone derivatives, namely, 2-methoxy-6-acetyl-7-methyljuglone (1), 2-ethoxy-6-acetyl-7-methyljuglone (2), 2-methoxy-7-acetonyljuglone (3), and 3-acetyl-7-methoxy-2-methyljuglone (4) together with two phenolics (5 and 6), an anthraquinone (7), a stilbene (8) and a phthalide (9). Their structures were elucidated on the basis of...
Αλέξανδρος Γ. Σφακιανάκης
1h
Pharmacal Research
Preventive approach for overcoming dementiaAbstractDementia is used as a general term to describe chronic disorders of mental processes caused by the deterioration of cognitive functions to the extent that one's ability to perform daily activities is impaired. Currently, age is known to be the main risk factor for dementia, suggesting that the risk of being diagnosed with dementia significantly increases later in one's life. Therefore, there are two approaches one can take when confronting dementia:...
Αλέξανδρος Γ. Σφακιανάκης
1h
Operative Orthopädie und Traumatologie
Spinale Navigation zur dorsalen zervikalen und zervikothorakalen InstrumentierungZusammenfassungOperationszielSichere Platzierung von zervikalen bzw. hoch-thorakalen Pedikelschrauben, transartikulären Schrauben C1/2, translaminären Schrauben oder zervikalen Massa-lateralis-Schrauben unter Verwendung der spinalen Navigation.IndikationenAlle dorsalen zervikalen und zervikothorakalen Instrumentierungen mit Schrauben: Instabilitäten und Deformitäten degenerativer, rheumatischer, traumatischer, neoplastischer,...
Αλέξανδρος Γ. Σφακιανάκης
1h
Serum Chemerin Levels Correlate With Determinants of Metabolic Syndrome in Obese Children and Adolescents...
Serum Chemerin Levels Correlate With Determinants of Metabolic Syndrome in Obese Children and AdolescentsHong-Jun Ba1, Ling-Ling Xu2, You-Zhen Qin1, Hong-Shan Chen2First Published June 5, 2019.https://doi.org/10.1177/1179556519853780AbstractHide PreviewAbstractObjectives:This study aimed to investigate serum chemerin concentrations in obese children and adolescents and to investigate the associations of chemerin with body mass index (BMI), lipid levels, and insulin sensitivity.Methods:Forty-eight...
Αλέξανδρος Γ. Σφακιανάκης
1h
Some Scars Do Not Run Deep: The Qualitative and Quantitative Nature of Neonatal Seldinger Pigtail Chest...
Some Scars Do Not Run Deep: The Qualitative and Quantitative Nature of Neonatal Seldinger Pigtail Chest Drain ScarsLeo BH Gundle1, Aimee Dowek2, Priya Heer2, Steven Jones4, David Bartle3First Published June 11, 2019.https://doi.org/10.1177/1179556519855384AbstractHide PreviewAbstractPneumothorax is a complication of respiratory distress syndrome, of which many preterm babies suffer. If significant, these pneumothoraces can be treated by the insertion of a chest drain. There are a number of different...
Αλέξανδρος Γ. Σφακιανάκης
1h
Self-Reported and Actual Involvement of Community Pharmacy Professionals in the Management of Childhood...
Self-Reported and Actual Involvement of Community Pharmacy Professionals in the Management of Childhood Diarrhea: A Cross-Sectional and Simulated Patient Study at two Towns of Eastern EthiopiaGetnet Mengistu1, Kassahun Gietnet2, Firehiwot Amare2, Mekonnen Sisay3, Bisrat Hagos4, Desye Misganaw1First Published June 13, 2019.https://doi.org/10.1177/1179556519855380AbstractHide PreviewAbstractBackground:Role of community pharmacy professionals is observed in the prevention and treatment of diarrhea and...
Αλέξανδρος Γ. Σφακιανάκης
1h
Time to Recovery of Feeding After Alveolar Bone Graft Is Associated With Postoperative Nausea and Vomiting...
Time to Recovery of Feeding After Alveolar Bone Graft Is Associated With Postoperative Nausea and Vomiting Within 2 Hours in ChildrenKaoru Yamashita1, Toshiro Kibe2, Sachi Ohno1, Minako Uchino1, Yurina Higa1, Ayako Niiro1, Norifumi Nakamura2, Mitsutaka Sugimura1First Published June 14, 2019.https://doi.org/10.1177/1179556519855387AbstractHide PreviewAbstractObjective:To examine the relationship between the method of anesthesia for alveolar bone graft surgery and postoperative nausea and vomiting...
Αλέξανδρος Γ. Σφακιανάκης
1h
Follicular Dendritic Cell Sarcoma or Not? A Series of 5 Diagnostically Challenging Cases Nicolas Lopez-Hisijos,...
Follicular Dendritic Cell Sarcoma or Not? A Series of 5 Diagnostically Challenging CasesNicolas Lopez-Hisijos, Reeba Omman, Stefan Pambuccian, Kamran MirzaFirst Published May 23, 2019.https://doi.org/10.1177/1179554919844531AbstractHide PreviewAbstractImperfect or unusual presentation, morphology, or immunophenotype can make the diagnosis of follicular dendritic cell sarcoma (FDCS) very challenging. To illustrate this, we present 5 unique cases from the archives of our tertiary care academic medical...
Αλέξανδρος Γ. Σφακιανάκης
1h
Improvement of Chemotherapy Solutions Production Procedure in a Hospital Central Chemotherapy Preparation...
Improvement of Chemotherapy Solutions Production Procedure in a Hospital Central Chemotherapy Preparation Unit: A Systematic Risk Assessment to Prevent Avoidable Harm in Cancer PatientsKlio Bourika1, Angelos Koutras2, Haralambos Kalofonos2, Anna Vicha3, Ekaterini Tsiata4, Evangelia Papadimitriou1, Konstantinos Avgoustakis5, Zoi Panagi4First Published June 10, 2019.https://doi.org/10.1177/1179554919852933AbstractHide PreviewAbstractObjective:This study was designed to reevaluate and improve the quality...
Αλέξανδρος Γ. Σφακιανάκης
1h
Dental Implants
Success or survival: Which race to win?Sharat ShettyJournal of Dental Implants 2019 9(1):1-3TTPHIL-ALL TILT™ – An effective technique for loading of dental implants: A comparative study of stress distribution in maxilla using finite element analysisP Venkat Ratna Nag, P Sarika, Ruheena Khan, Tejashree BhagwatkarJournal of Dental Implants 2019 9(1):4-11Objectives: The key objective of the study is to compare the influence of stress on the bone after placement of dental implants using three alternative...
Αλέξανδρος Γ. Σφακιανάκης
1h
D-dimer: A biomarker for antihistamine-resistant chronic urticaria Riccardo Asero, MDEmail the author...
D-dimer: A biomarker for antihistamine-resistant chronic urticariaRiccardo Asero, MDEmail the author MD Riccardo AseroAmbulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan, ItalyPlumX MetricsDOI: https://doi.org/10.1016/j.jaci.2013.04.037Article InfoPublication HistoryPublished online:June 13, 2013AbstractFull TextImagesReferencesTo the Editor:Chronic urticaria (CU) may affect up to 1% of the general population at some point in life and can severely impair quality of life. Most patients...
Αλέξανδρος Γ. Σφακιανάκης
1h
Successful omalizumab treatment in chronic spontaneous urticaria is associated with lowering of serum...
Successful omalizumab treatment in chronic spontaneous urticaria is associated with lowering of serum IL-31 levels.Altrichter S1, Hawro T1, Hänel K2,3, Czaja K2, Lüscher B3, Maurer M1, Church MK1, Baron JM2.Author information1Department of Dermatology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.2Department of Dermatology and Allergology, Medical School RWTH Aachen University, Aachen, Germany.3Medical School RWTH Aachen University, Institute of Biochemistry and Molecular...
Αλέξανδρος Γ. Σφακιανάκης
1h
Subcutaneous injection of histaglobulin,which is a combination of human normal immunoglobulin (12 mg) and histamine dihydrochloride (0.15 mcg).1 ml of histaglobulin subcutaneously over the arm, weekly for 8 consecutive weeks. Patients were also prescribed rescue medication (tablet levocetirizine 5 mg) to be taken when required, not exceeding the permitted daily dosage.
Indian J Pharmacol. doi: 10.4103/0253-7613.182884PMCID: PMC4900003PMID: 27298500Weekly injection of histaglobulin produces long-term remission in chronic urticaria: A prospective clinical studyGurumoorthy Rajesh, Subramaniam Keerthi, Kaliaperumal Karthikeyan, and Murugan Venkatesan1Author information Article notes Copyright and License information DisclaimerDepartment of Dermatology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India1Department of Community Medicine, Sri Manakula...
Αλέξανδρος Γ. Σφακιανάκης
1h
Both histaglobin and histaglobin-triplex proved effective in CAR and CRU when routine treatment failed.Continuous allergic rhinitis (CAR) and chronic recurrent (idiopathic) urticaria (CRU),Histaglobin drugs (histaglobin and histaglobin-triplex),The drugs were injected subcutaneously (a total of 6 injections, 2 ml of solution each) with the interval 2-3 or 3-4 days. Histaglobin was given as 12 mg of normal human immunoglobulin + 0.00015 mg of histamine dihydrochloride. Histamine-triplex as 36 mg of immunoglobulin + 0.00045 mg of histamine dihydrochloride. The treatment was repeated in a months (3 injections).
Ter Arkh. [Therapeutic effectiveness of histaglobin preparations in patients with allergic rhinitis and chronic urticaria].[Article in Russian]Gushchin IS, Luss LV, Il'ina NI, Larina ON, Pakhomova LA.AbstractAIM:To evaluate therapeutic effects of histaglobin drugs (histaglobin and histaglobin-triplex) in patients with continuous allergic rhinitis (CAR) and chronic recurrent (idiopathic) urticaria (CRU).MATERIALS AND METHODS:The drugs were given to 45 patients with CAR and high sensitivity to household...
Αλέξανδρος Γ. Σφακιανάκης
1h
Gastric cancer and intrahepatic cholangiocarcinoma: Gastrectomy followed by left hepatectomy to achieve...
Gastric cancer and intrahepatic cholangiocarcinoma: Gastrectomy followed by left hepatectomy to achieve R0 resectionAlex Emmanuel Elobu, Ashok Thorat, Vianney Kweyamba, Rakesh RaiFormosan Journal of Surgery 2019 52(3):107-109Gastric cancer is the fifth most common cancer and the third leading cause of cancer deaths globally. Its incidence is highest in Asia and lowest in Africa. In 1.1%–4.7% of all gastric cancer cases, at least one other primary tumor may be found. We present the case of a 55-year-old...
Αλέξανδρος Γ. Σφακιανάκης
1h
Long-term survival of a patient with advanced hepatoid type adenocarcinoma of stomach and liver metastasis...
Long-term survival of a patient with advanced hepatoid type adenocarcinoma of stomach and liver metastasisChao-Chien Hung, Tsung-Jung Liang, Huai-Pao Lee, I-Shu ChenFormosan Journal of Surgery 2019 52(3):103-106Hepatoid adenocarcinoma is a rare variant of gastric cancer, and exhibits most of the characteristics of alpha-fetoprotein-secreting cancer; it has been reported to have poor outcomes irrespective of the treatment used. Here, we report a case wherein a relatively favorable outcome was obtained...
Αλέξανδρος Γ. Σφακιανάκης
1h
Multiple massive intratumoral hemorrhages of metastatic brain melanoma after ventriculoperitoneal shunt...
Multiple massive intratumoral hemorrhages of metastatic brain melanoma after ventriculoperitoneal shuntTsung-Hsi Yang, Jung-Tung Liu, Fook-How ChanFormosan Journal of Surgery 2019 52(3):99-102A 50-year-old male presented with sudden-onset headache, diplopia, and unsteadiness due to a posterior fossa hemorrhagic melanoma causing hydrocephalus. Computed tomography of the brain showed a 2.3 cm × 2.0 cm hemorrhagic tumor in the cerebellar vermis and a concomitant fourth ventricular hemorrhage. He underwent...
Αλέξανδρος Γ. Σφακιανάκης
1h
Using donor ascending aorta for venous reconstruction in a situs inversus heart transplantation Jenn-Yeu...
Using donor ascending aorta for venous reconstruction in a situs inversus heart transplantationJenn-Yeu Song, Yi-Ting Tsai, Ta-Chung Shen, Chien-Sung TsaiFormosan Journal of Surgery 2019 52(3):96-98A 66-year-old female was a case of situs inversus that developed heart failure. Heart transplantation was performed with the modified method. While we harvested the donor's heart, we left an extra-aortic conduit in the ascending aorta. Donor's superior vena cava (SVC) and inferior vena cava were also retained...
Αλέξανδρος Γ. Σφακιανάκης
2h
Obstructive tracheal neoplasm: Imaging and therapeutical features of pleomorphic adenoma Badreeddine...
Obstructive tracheal neoplasm: Imaging and therapeutical features of pleomorphic adenomaBadreeddine Alami, Saïd Boujraf, Mohamed Smahi, Mounia Serraj, Moulay Youssef Alaoui Lamrani, Meryem Boubbou, Mustapha MaaroufiFormosan Journal of Surgery 2019 52(3):92-95Primary tumor of the trachea is rare. Although most tumors in adults are malignant, various benign tumors might occur. However, pleomorphic adenoma of the trachea is extremely rare. So far, few cases have been reported in medical literature....
Αλέξανδρος Γ. Σφακιανάκης
2h
Surgery
Formosan Journal of SurgeryLong-term surgical outcome of median nerve injuriesMohammadreza Emamhadi, Hamid Behzadnia, Sasan AndalibFormosan Journal of Surgery 2019 52(3):71-75Background: Median nerve integrity is a prerequisite of normal hand function. The median nerve is a frequently injured nerve, and recent evidence indicates that nerve surgery may produce acceptable outcomes. The present study provides a framework of long-term surgical outcomes of median nerve injuries and specifies independent...
Αλέξανδρος Γ. Σφακιανάκης
2h
The 25th anniversary of the UN World Day to Combat Desertification (#2019WDCD)
The 25th anniversary of the UN World Day to Combat Desertification (#2019WDCD) Water resource system risk and adaptive management of the Chinese Heihe River Basin in Asian arid areasWater in Central Asia: an integrated assessment for science-based managementThe Significance of Land Cover Delineation on Soil Erosion AssessmentThe measurement of water scarcity: Defining a meaningful indicatorSpatio-temporal characteristics and driving forces of landscape structure changes in the middle reach of the...
Αλέξανδρος Γ. Σφακιανάκης
2h
Negative emissions of carbon dioxide through chemical-looping combustion (CLC) and gasification (CLG)...
Negative emissions of carbon dioxide through chemical-looping combustion (CLC) and gasification (CLG) using oxygen carriers based on manganese and ironAbstractCarbon capture and storage (CCS) is an economically attractive strategy for avoiding carbon dioxide (CO2) emissions from, e.g., power plants to the atmosphere. The combination of CCS and biomass combustion would result in a reduction of atmospheric CO2, or net negative emissions, as plant growth is a form of sequestration of atmospheric carbon....
Αλέξανδρος Γ. Σφακιανάκης
2h
Quantifying greenhouse gas emissions Abstract The assessment of greenhouse gases (GHGs) and air pollutants...
Quantifying greenhouse gas emissionsAbstractThe assessment of greenhouse gases (GHGs) and air pollutants emitted to and removed from the atmosphere ranks high on international political and scientific agendas. Growing international concern and cooperation regarding the climate change problem have increased the need to consider the uncertainty in inventories of GHG emissions. The approaches to address uncertainty discussed in this special issue reflect attempts to improve national inventories, not...
Αλέξανδρος Γ. Σφακιανάκης
2h
Mitigation and Adaptation Strategies for Global Change An International Journal Devoted to Scientific,...
Mitigation and Adaptation Strategies for Global ChangeAn International Journal Devoted to Scientific, Engineering, Socio-Economic and Policy Responses to Environmental ChangeISSN: 1381-2386 (Print) 1573-1596 (Online)DescriptionWe are pleased to announce that Mitigation and Adaptation Strategies for Global Change has been accepted in September 2010 by Thomson Reuters (formerly ISI) for inclusion in the Science Citation Index Expanded (also known as SciSearch®), Journal Citation Reports/Science Edition,...
Αλέξανδρος Γ. Σφακιανάκης
2h
Arid Land
Journal of Arid LandISSN: 1674-6767 (Print) 2194-7783 (Online)DescriptionCo-sponsored by Xinjiang Institute of Ecology and Geography, the Chinese Academy of Sciences and Science Press, the Journal of Arid Land is an international peer-reviewed journal which explores sustainable development and eco-environmental management and focuses on the arid and semi-arid lands in Central Asia and the world at large.The journal covers such topics as the dynamics of natural resources (including water, soil and...
Αλέξανδρος Γ. Σφακιανάκης
2h
Climate change and uncertainty from 'above' and 'below' : perspectives from India Abstract Climate-related...
Climate change and uncertainty from 'above' and 'below': perspectives from IndiaAbstractClimate-related uncertainty refers to the inability to predict the scale, intensity, and impact of climate change on human and natural environments. Debates of uncertainty in climate change have emerged as a 'super wicked' problem for scientists and policy makers alike. The article draws on ongoing research in different socio-ecological and cultural settings in India (Kutch, the Sundarbans and Mumbai) and introduces...
Αλέξανδρος Γ. Σφακιανάκης
2h
Regional Environmental Change
Climate change and uncertainty from 'above' and 'below': perspectives from IndiaAbstractClimate-related uncertainty refers to the inability to predict the scale, intensity, and impact of climate change on human and natural environments. Debates of uncertainty in climate change have emerged as a 'super wicked' problem for scientists and policy makers alike. The article draws on ongoing research in different socio-ecological and cultural settings in India (Kutch, the Sundarbans and Mumbai) and introduces...
Αλέξανδρος Γ. Σφακιανάκης
2h

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