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Δευτέρα 1 Ιουλίου 2019

ACS chemical biology


Neuronal Calcium Recording with an Engineered TEV Protease.
Related ArticlesNeuronal Calcium Recording with an Engineered TEV Protease. ACS Chem Biol. 2018 05 18;13(5):1159-1164 Authors: O'Neill BK, Laughlin ST Abstract Technologies for measuring the transient Ca2+ spikes that accompany neural signaling have revolutionized our understanding of the brain. Nevertheless, microscopic visualization of Ca2+ spikes on the time scale of neural activity across large brain regions or in thick specimens remains a significant...
pubmed: "acs chem biol"[jour...
Sun Jun 30, 2019 13:53
Nonmicrobicidal Small Molecule Inhibition of Polysaccharide Metabolism in Human Gut Microbes: A Potential Therapeutic Avenue.
Related ArticlesNonmicrobicidal Small Molecule Inhibition of Polysaccharide Metabolism in Human Gut Microbes: A Potential Therapeutic Avenue. ACS Chem Biol. 2018 05 18;13(5):1165-1172 Authors: Santilli AD, Dawson EM, Whitehead KJ, Whitehead DC Abstract A new approach for the nonmicrobicidal phenotypic manipulation of prominent gastrointestinal microbes is presented. Low micromolar concentrations of a chemical probe, acarbose, can selectively inhibit...
pubmed: "acs chem biol"[jour...
Sun Jun 30, 2019 13:53
Mechanism of Action of the Cytotoxic Asmarine Alkaloids.
Related ArticlesMechanism of Action of the Cytotoxic Asmarine Alkaloids. ACS Chem Biol. 2018 05 18;13(5):1299-1306 Authors: Lambrecht MJ, Kelly JW, Shenvi RA Abstract The asmarines are a family of cytotoxic natural products whose mechanism of action is unknown. Here, we used chemical synthesis to reverse engineer the asmarines and understand the functions of their individual components. We found that the potent asmarine analog "delmarine" arrested the...
pubmed: "acs chem biol"[jour...
Sun Jun 30, 2019 13:53
Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins.
Related ArticlesAnticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins. ACS Chem Biol. 2018 05 18;13(5):1380-1387 Authors: Li BX, Chen J, Chao B, David LL, Xiao X Abstract Target identification of bioactive compounds is critical for understanding their mechanism of action. We previously discovered a novel pyrroloquinazoline compound LBL1 with significant anticancer activity. However, its molecular targets remain to be established. Herein, we developed...
pubmed: "acs chem biol"[jour...
Sun Jun 30, 2019 13:53
O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry.
Related ArticlesO-GlcNAcase Fragment Discovery with Fluorescence Polarimetry. ACS Chem Biol. 2018 05 18;13(5):1353-1360 Authors: Borodkin VS, Rafie K, Selvan N, Aristotelous T, Navratilova I, Ferenbach AT, van Aalten DMF Abstract The attachment of the sugar N-acetyl-D-glucosamine (GlcNAc) to specific serine and threonine residues on proteins is referred to as protein O-GlcNAcylation. O-GlcNAc transferase (OGT) is the enzyme responsible for carrying...
pubmed: "acs chem biol"[jour...
Sun Jun 30, 2019 13:53
Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy.
Related ArticlesChemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy. ACS Chem Biol. 2018 05 18;13(5):1148-1152 Authors: Contreras JI, Robb CM, King HM, Baxter J, Crawford AJ, Kour S, Kizhake S, Sonawane YA, Rana S, Hollingsworth MA, Luo X, Natarajan A Abstract The study presented here provides a framework for the discovery of unique inhibitor combinations that target the apoptosis network...
pubmed: "acs chem biol"[jour...
Sun Jun 30, 2019 13:53

Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2- trans-Hexadecenal.
Related ArticlesChemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2- trans-Hexadecenal. ACS Chem Biol. 2018 05 18;13(5):1130-1136 Authors: Jarugumilli GK, Choi JR, Chan P, Yu M, Sun Y, Chen B, Niu J, DeRan M, Zheng B, Zoeller R, Lin C, Wu X Abstract Lipid-derived electrophiles (LDEs) are reactive metabolites, which can covalently modify proteins and DNA and regulate diverse cellular processes. 2- trans-Hexadecenal (2-HD)...
pubmed: "acs chem biol"[jour...
Sun Jun 30, 2019 13:53
A Common Mechanism Links Activities of Butyrate in the Colon.
Related ArticlesA Common Mechanism Links Activities of Butyrate in the Colon. ACS Chem Biol. 2018 05 18;13(5):1291-1298 Authors: Verma MS, Fink MJ, Salmon GL, Fornelos N, Ohara TE, Ryu SH, Vlamakis H, Xavier RJ, Stappenbeck TS, Whitesides GM Abstract Two biological activities of butyrate in the colon (suppression of proliferation of colonic epithelial stem cells and inflammation) correlate with inhibition of the activity of histone deacetylases. Cellular...
pubmed: "acs chem biol"[jour...
Sun Jun 30, 2019 13:53
A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance.
Related ArticlesA Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance. ACS Chem Biol. 2018 05 18;13(5):1189-1199 Authors: Matthews JH, Liang X, Paul VJ, Luesch H Abstract Resistance to chemotherapy is a major obstacle in the treatment of a wide array of different types of cancer. Chemotherapeutic drug resistance is achieved by cancer cells...
pubmed: "acs chem biol"[jour...
Sun Jun 30, 2019 13:53
Optical and Structural Characterization of a Chronic Myeloid Leukemia DNA Biosensor.
Related ArticlesOptical and Structural Characterization of a Chronic Myeloid Leukemia DNA Biosensor. ACS Chem Biol. 2018 05 18;13(5):1235-1242 Authors: Cordeiro M, Otrelo-Cardoso AR, Svergun DI, Konarev PV, Lima JC, Santos-Silva T, Baptista PV Abstract Selective base pairing is the foundation of DNA recognition. Here, we elucidate the molecular and structural details of a FRET-based two-component molecular beacon relying on steady-state fluorescence...
pubmed: "acs chem biol"[jour...
Sun Jun 30, 2019 13:53
Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8.
Related ArticlesMultiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8. ACS Chem Biol. 2018 05 18;13(5):1279-1290 Authors: Eron SJ, MacPherson DJ, Dagbay KB, Hardy JA Abstract Zinc is emerging as a widely used and important biological regulatory signal. Cellular zinc levels are tightly regulated by a complex array of zinc importers and exporters to control processes such as apoptotic cell death. While caspase inhibition...
pubmed: "acs chem biol"[jour...
Sun Jun 30, 2019 13:53
Live Cell Visualization of Multiple Protein-Protein Interactions with BiFC Rainbow.
Related ArticlesLive Cell Visualization of Multiple Protein-Protein Interactions with BiFC Rainbow. ACS Chem Biol. 2018 05 18;13(5):1180-1188 Authors: Wang S, Ding M, Xue B, Hou Y, Sun Y Abstract As one of the most powerful tools to visualize PPIs in living cells, bimolecular fluorescence complementation (BiFC) has gained great advancement during recent years, including deep tissue imaging with far-red or near-infrared fluorescent proteins or super-resolution...
pubmed: "acs chem biol"[jour...
Sun Jun 30, 2019 13:53

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