Autoimmune Neuropathies associated to Rheumatic Diseases

Publication date: Available online 12 February 2017
Source:Autoimmunity Reviews
Author(s): Alberto R.M. Martinez, Ingrid Faber, Anamarli Nucci, Simone Appenzeller, Marcondes C. França
Systemic manifestations are frequent in autoimmune rheumatic diseases and include peripheral nervous system damage. Neuron cell body, axons and myelin sheath may all affected in this context. This involvement results in severe and sometimes disabling symptoms. Sensory, motor and autonomic features may be present in different patterns that emerge as peculiar clinical pictures. Prompt recognition of these neuropathies is pivotal to guide treatment and reduce the risks of long term disability. In this review, we aim to describe the main immune-mediated neuropathies associated to rheumatic diseases: sensory neuronopathies, multiple mononeuropathies and chronic inflammatory demyelinating polyradiculoneuropathy, with an emphasis on clinical features and therapeutic options.



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