LIPID METABOLISM AND LUNG CANCER

Publication date: Available online 13 February 2017
Source:Critical Reviews in Oncology/Hematology
Author(s): María Merino Salvador, Marta Gómez de Cedrón, Juan Moreno Rubio, Sandra Falagán Martínez, Ruth Sánchez Martínez, Enrique Casado, Ana Ramírez de Molina, María Sereno
Lung cancer is currently one of the most serious health issues in developed and developing countries. There are multiple available treatment options; however survival still remains very poor. Despite metabolism alteration being one of the hallmarks described in human cancer, lipid metabolism disorders are less known. They are recently becoming more important in this setting and therefore achieving a deeper knowledge might be helpful to obtain new strategies to accurate diagnosis, estimate prognosis, and develop therapeutic agents based on bioactive compounds such as cerulenin, SCD1, ACLY inhibitors, statins, polyphenolic compounds, etc. The present paper reviews the basis of lipid metabolism in lung cancer and suggests potential biomarkers. Further investigation is crucial to improve our knowledge in this area.



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