B cell activating factor (BAFF) selects IL-10−B cells over IL-10+B cells during inflammatory responses

Publication date: May 2017
Source:Molecular Immunology, Volume 85
Author(s): Ning Ma, Yu Zhang, Qilin Liu, Zhiding Wang, Xiaoling Liu, Gaizhi Zhu, Dandan Yu, Gencheng Han, Guojiang Chen, Chunmei Hou, Tianxiao Wang, Yuanfang Ma, Beifen Shen, Yan Li, He Xiao, Renxi Wang
B cell activating factor (BAFF) regulates B cell maturation, survival, function, and plays a critical pathogenic role in autoimmune diseases. It remains unclear how BAFF affects IL-10⁻B cells versus regulatory B cells (Bregs) in inflammatory responses. In this study, we found that IL-10-expressing Bregs decreased in lupus-prone MRL/lpr mice and experimental allergic encephalomyelitis (EAE) mice. On blockade of the effects of BAFF with TACI-IgG, IL-10⁺ Bregs were upregulated in MRL/lpr and EAE mice. In addition, BAFF expanded IL-10⁺B cells over IL-10⁻B cells under noninflammatory conditions in vitro, whereas it expanded IL-10⁻B cells over IL-10⁺B cells during inflammatory responses, such as stimulation with autoantigen and LPS. Finally, the selection of IL-10⁻B cells over IL-10⁺B cells by BAFF was dependent on BAFF receptors (BAFFR, TACI, and BCMA) that were upregulated by inflammatory responses. This study suggests that BAFF selects IL-10⁻B cells over IL-10⁺ regulatory B cells via BAFF receptors in inflammatory responses.



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