Microparticles: Inflammatory and haemostatic biomarkers in Polycystic Ovary Syndrome

Publication date: 5 March 2017
Source:Molecular and Cellular Endocrinology, Volume 443
Author(s): L.M.L. Carvalho, C.N. Ferreira, M.O. Sóter, M.F. Sales, K.F. Rodrigues, S.R. Martins, A.L. Candido, F.M. Reis, I.F.O. Silva, F.M.F. Campos, K.B. Gomes
Polycystic Ovary Syndrome (PCOS) is associated with a chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications. This case-control study evaluated the microparticles (MPs) profile in patients with the PCOS and related these MPs to clinical and biochemical parameters. MPs derived from platelets (PMPs), leuckocytes (LMPs) and endothelial cells (EMPs) were evaluated, as well as MPs expressing tissue factor (TFMPs), by flow cytometry, comparing women with PCOS (n = 50) and a healthy control group (n = 50). PCOS women presented increased total MPs, PMPs, LMPs and EMPs levels when compared to control group (all p < 0.05). TFMPs was similar between the groups (p = 0.379). In conclusion, these MPs populations could be useful biomarkers for association with thrombosis and cardiovascular disease in PCOS women.



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