Prospects for a Zika Virus Vaccine

Publication date: 21 February 2017
Source:Immunity, Volume 46, Issue 2
Author(s): Dan H. Barouch, Stephen J. Thomas, Nelson L. Michael
A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated with microcephaly and other congenital malformations in infants as well as Guillain-Barre syndrome in adults. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Promising data from preclinical vaccine studies in mice and monkeys suggest that an effective vaccine will likely be possible, but important scientific challenges remain. Here we review the current state of ZIKV vaccine development. We discuss different vaccination strategies and we highlight challenges facing clinical evaluation of ZIKV vaccine candidates.

Teaser

The development of a safe and effective Zika virus (ZIKV) vaccine is an urgent global health priority. Barouch et al. review the current state of ZIKV vaccine development and highlight challenges facing clinical evaluation of ZIKV vaccine candidates.


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