Ετικέτες

Κυριακή 19 Μαρτίου 2017

Cross-protection to new drifted influenza A(H3) viruses and prevalence of protective antibodies to seasonal influenza, during 2014 in Portugal

S0264410X.gif

Publication date: Available online 18 March 2017
Source:Vaccine
Author(s): Raquel Guiomar, Susana Pereira da Silva, Patrícia Conde, Paula Cristóvão, Ana Carina Maia, Pedro Pechirra, Ana Paula Rodrigues, Baltazar Nunes, Luís Milho, Ana Paula Coelho, Aida Fernandes, Paula Caseiro, Fernando Rodrigues, Lurdes Correia, João Pereira-Vaz, Sofia Almeida, Paula Branquinho, Rita Côrte-Real, Regina Viseu, Maria João Peres, Raquel Sanches, Filipa Dantas, Ludovina Freitas, Graça Andrade, Manuel Maurílio, Filomena Caldeira, Rita Cabral Veloso, Luisa Mota-Vieira, Marta Soares, Ana Rita Couto, Jácome Bruges-Armas, Rita Mouro Pinto, Joana Sobrinho Simões, Maria do Rosário Costa, João Tiago Guimarães, Luís Martins, Mário Cunha
IntroductionImmune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portuguese population.Materials and methodsWe developed a cross-sectional study based on a convenience sample of 626 sera collected during June 2014, covering all age groups, both gender and all administrative health regions of Portugal. Sera antibody titers for seasonal and new A(H3) drift influenza virus were evaluated by hemagglutination inhibition assay (HI). Seroprevalence to each seasonal influenza vaccine strain virus and to the new A(H3) drift circulating strain was estimated by age group, gender and region and compared with seasonal influenza-like illness (ILI) incidence rates before and after the study period.ResultsOur findings suggest that seroprevalences of influenza A(H3) (39.9%; 95% CI: 36.2–43.8) and A(H1)pdm09 (29.7%; 95% CI: 26.3–33.4) antibodies were higher than for influenza B, in line with high ILI incidence rates for A(H3) followed by A(H1)pdm09, during 2013/2014 season. Low pre-existing cross-protection against new A(H3) drift viruses were observed in A(H3) seropositive individuals (46%). Both against influenza A(H1)pdm09 and A(H3) seroprotection was highest in younger than 14-years old. Protective antibodies against influenza B were highest in those older than 65years old, especially for B/Yamagata lineage, 33.3% (95% CI: 25.7–41.9). Women showed a high seroprevalence to influenza, although without statistical significance, when compared to men. A significant decreasing trend in seroprotection from north to south regions of Portugal mainland was observed.ConclusionsOur results emphasize that low seroprotection increases the risk of influenza infection in the following winter season. Seroepidemiological studies can inform policy makers on the need for vaccination and additional preventive measures.



http://ift.tt/2n3ioLb

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Αναζήτηση αυτού του ιστολογίου