NICE DSU Technical Support Document 11: Alternatives to EQ-5D for Generating Health State Utility Values [Internet].

The NICE Guide to the Methods of Technology Appraisal expresses a preference for using the EQ-5D for adult populations to estimate the Quality Adjusted Life Year (QALY) impact of different technologies. Alternative methods to generating health state utility values (HSUVs) will be considered by NICE in place of EQ-5D when EQ-5D data are either unavailable or inappropriate. Unavailability should be established from a systematic search of the literature. Even if EQ-5D data is unavailable, mapping can be used as an alternative to estimate EQ-5D values rather than the alternative methods described in this Technical Support Guide (see TSD 101). Claims that EQ-5D is inappropriate for measuring the Health Related Quality of Life (HRQL) for a patient group or a specific treatment must be supported by evidence.

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