Clinical utility of contrast-enhanced spectral mammography as an adjunct for tomosynthesis-detected architectural distortion

Publication date: Available online 12 July 2017
Source:Clinical Imaging
Author(s): Bhavika K. Patel, Michelle E. Naylor, Heidi E. Kosiorek, Yania M. Lopez-Alvarez, Adrian M. Miller, Victor J. Pizzitola, Barbara A. Pockaj
ObjectiveSupplement tomosynthesis-detected architectural distortions (AD) with CESM to better characterize malignant vs benign lesions.MethodsRetrospective review CESM prior to biopsied AD. Pathology: benign, radial scar, or malignant.Results49 lesions (45 patients). 29 invasive, 1 DCIS (range, 0.4–4.7cm); 9 radial scars; 10 benign. 37 (75.5%) ADs had associated enhancement. PPV 78.4% (29/37), sensitivity 96.7% (29/30); specificity, 57.9% (11/19); NPV, 91.7% (11/12). False-positive rate 21.6% (8/37); false-negative rate, 8.3% (1/12). Accuracy 81.6% (40/49).ConclusionsHigh sensitivity and NPV of CESM in patients with AD is promising as an adjunct tool in diagnosing malignancy and avoiding unnecessary biopsy, respectively.



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