Delaying Implant-Based Mammary Reconstruction After Radiotherapy Does Not Decrease Capsular Contracture: An In Vitro Study

We read with great interest the article entitled "Delaying Implant-Based Mammary Reconstruction After Radiotherapy Does Not Decrease Capsular Contracture: An In Vitro Study (J Plast Reconstr Aesthet Surg. 2017 June; pii: S1748-6815(17)30256-5). El-Diwany et al. have published a very interesting in-vitro study about fibrosis and capsular contracture after radiotherapy (RT). In this study they demonstrated with in vitro experiments that RT causes irreversible cellular changes which permanently alter the microenvironment in favour of fibrosis so that delaying breast reconstruction does not decrease the percentage of capsular contracture.

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