A Tale of Two Elabela Null Mice

Publication date: Available online 27 September 2017
Source:Trends in Endocrinology & Metabolism
Author(s): Irinna Papangeli, Hyung J. Chun
Elabela (ELA), the second peptide ligand for the apelin receptor, APLNR, was previously found in lower vertebrates to be crucial for endoderm and cardiac development. Two new studies report on the phenotypes of Ela null mice, ranging from defective embryogenesis to preeclampsia, providing new insights and raising greater intrigue on this cardiometabolic pathway.



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