Genistein: its role in metabolic diseases and cancer

Publication date: Available online 12 September 2017
Source:Critical Reviews in Oncology/Hematology
Author(s): Vidya Mukund, Dhruv Mukund, Vinay Sharma, Mastan Mannarapu, Afroz Alam
Genistein is an isoflavone present in soy and is known to have multiple molecular effects, such as the inhibition of inflammation, promotion of apoptosis, and modulation of steroidal hormone receptors and metabolic pathways. Since these molecular effects impact carcinogenesis, cancer propagation, obesity, osteoporosis, and metabolic syndromes, genistein plays an important role in preventing and treating common disorders. The role of genistein has not been adequately evaluated in all these clinical settings. This review summarizes some of the known molecular effects of genistein and its potential role in health maintenance and treatment.



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