The Unsolved Problem of How Cells Sense Micron-Scale Curvature

Publication date: Available online 28 October 2017
Source:Trends in Biochemical Sciences
Author(s): Kevin S. Cannon, Benjamin L. Woods, Amy S. Gladfelter
Membrane curvature is a fundamental feature of cells and their organelles. Much of what we know about how cells sense curved surfaces comes from studies examining nanometer-sized molecules on nanometer-scale curvatures. We are only just beginning to understand how cells recognize curved topologies at the micron scale. In this review, we provide the reader with an overview of our current understanding of how cells sense and respond to micron-scale membrane curvature.



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