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Κυριακή 29 Οκτωβρίου 2017

White-matter microstructure and hearing acuity in older adults: a population-based cross-sectional DTI study

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Publication date: January 2018
Source:Neurobiology of Aging, Volume 61
Author(s): Stephanie C. Rigters, Lotte G.M. Cremers, M. Arfan Ikram, Marc P. van der Schroeff, Marius de Groot, Gennady V. Roshchupkin, Wiro J.N. Niessen, Robert J. Baatenburg de Jong, André Goedegebure, Meike W. Vernooij
To study the relation between the microstructure of white matter in the brain and hearing function in older adults we carried out a population-based, cross-sectional study. In 2562 participants of the Rotterdam Study, we conducted diffusion tensor imaging to determine the microstructure of the white-matter tracts. We performed pure-tone audiogram and digit-in-noise tests to quantify hearing acuity. Poorer white-matter microstructure, especially in the association tracts, was related to poorer hearing acuity. After differentiating the separate white-matter tracts in the left and right hemisphere, poorer white-matter microstructure in the right superior longitudinal fasciculus and the right uncinate fasciculus remained significantly associated with worse hearing. These associations did not significantly differ between middle-aged (51–69 years old) and older (70–100 years old) participants. Progressing age was thus not found to be an effect modifier. In a voxel-based analysis no voxels in the white matter were significantly associated with hearing impairment.



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