Volume Conduction Coupling of Whisker-Evoked Cortical LFP in the Mouse Olfactory Bulb

Publication date: 24 October 2017
Source:Cell Reports, Volume 21, Issue 4
Author(s): Ana Parabucki, Ilan Lampl
Local field potentials (LFPs) are an important measure of brain activity and have been used to address various mechanistic and behavioral questions. We revealed a prominent whisker-evoked LFP signal in the olfactory bulb and investigated its physiology. This signal, dependent on barrel cortex activation and highly correlated with its local activity, represented a pure volume conduction signal that was sourced back to the activity in the ventro-lateral orbitofrontal cortex, located a few millimeters away. Thus, we suggest that special care should be taken when acquiring and interpreting LFP data.

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Teaser

Local field potential (LFP) recordings are an important yet still obscure tool in neuroscience. In this issue, Parabucki and Lampl show volume conduction of LFP signals from cortex to olfactory bulb in mice, emphasizing that LFP can be misleading under certain circumstances.


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