Autophagy in Neurodegeneration: Can’t Digest It, Spit It Out!

Publication date: Available online 31 January 2018
Source:Trends in Cell Biology
Author(s): Valentin J.A. Barthet, Kevin M. Ryan
The autophagy-lysosome pathway maintains cellular homeostasis and protects against neurodegenerative disorders. Recent findings show that autophagy can be impaired in these diseases, and that the cell activates an alternative Golgi-mediated degradation pathway, leading to expulsion of toxic protein aggregates. Ultimately this process leads to nuclear breakdown and neuronal cell death.



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