Novel Insights into NDP52 Autophagy Receptor Functioning

Publication date: Available online 31 January 2018
Source:Trends in Cell Biology
Author(s): Christophe Viret, Aurore Rozières, Mathias Faure
NDP52/CALCOCO2 makes multiple contributions to selective autophagy. By interacting with cargos and LC3, NDP52 directs autophagy targets to autophagosomes. In addition, NDP52 promotes autophagosomes fusion with endolysosomes by connecting autophagosomes to MYOSIN VI. Recent studies reveal that Rab35 GTPase controls NDP52 recruitment to its targets and that NDP52 triggers MYOSIN VI (MYO6) motility.



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