Development of a stereoselective and scalable process for the preparation of a methylcyclobutanol-pyridyl ether

Publication date: 15 February 2018
Source:Bioorganic & Medicinal Chemistry, Volume 26, Issue 4
Author(s): Jeffrey T. Kuethe, Kallol Basu, Robert K. Orr, Eric Ashley, Marc Poirier, Lushi Tan
The evolution of a scalable process for the preparation of methylcyclobutanol-pyridyl ether 1 is described. Key aspects of this development including careful control of the stereochemistry, elimination of chromatography, and application to kilogram-scale synthesis are addressed.

Graphical abstract

http://ift.tt/2F8EAej