Immune cells involved in the pathogenesis of ankylosing spondylitis

Publication date: April 2018
Source:Biomedicine & Pharmacotherapy, Volume 100
Author(s): Alireza Rezaiemanesh, Mohsen Abdolmaleki, Kamal Abdolmohammadi, Hamideh Aghaei, Fatemeh Dadgar Pakdel, Yousef Fatahi, Narjes Soleimanifar, Mahdi Zavvar, Mohammad Hossein Nicknam
Ankylosing spondylitis (AS) is an inflammatory autoimmune disease. AS is a prototype form of spondyloarthropathies (SpA). The precise etiology of AS has not been fully understood. But Inflammation has a critical role in the pathogenesis of the disease. The immune system by various cells, secreted-mediators and markers manage and regulate the immune responses and inflammation. Every factor which disturbed this regulation and hemostasis can cause chronic inflammation. In this review, we discussed the role of several innate and adaptive immune cells involved in the triggering, initiation, development, and regulation of AS.



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