FISH-ing Novel Dynamic Modes of Glucocorticoid-Induced Chromatin Reorganization

Publication date: Available online 21 February 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Felicity E. Stubbs, Benjamin P. Flynn, Becky L. Conway-Campbell
In a recent study, Jubb et al. used 3D DNA FISH to assess glucocorticoid-induced 'chromatin decompaction' at multiple loci. Determinants of the specificity, speed, and duration of this phenomenon further enhance our understanding of how the glucocorticoid receptor (GR) dynamically alters chromatin accessibility during acute-phase transcriptional regulation and beyond.



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