Hypothalamic Sensing of Bile Acids, a Gut Feeling

Publication date: Available online 21 February 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Allison W. Xu
Bile acids facilitate dietary fat absorption upon release into the small intestine after a meal. A recent study by Liu and colleagues identifies a gut–brain axis wherein bile acids signal an energy-replete state to hypothalamic AgRP neurons via activation of neuronal FGF receptors, which orchestrate whole-body glucose metabolism.



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