Lean ApoM−/− Mice with Hyperactive Brown Adipose Tissue

Publication date: Available online 13 March 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Björn Dahlbäck
In Cell Reports, Christoffersen et al. [1] demonstrate that sphingosine 1-phosphate (S1P) bound to apolipoprotein M (apoM) regulates the activity and mass of brown adipose tissue (BAT). They found mice lacking apoM to have hyperactive BAT with high triglyceride (TG) utilization, resulting in low white adipose tissue (WAT) mass and low body weight.



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