Altered Cellular Metabolism Drives Trained Immunity

Publication date: Available online 5 April 2018
Source:Trends in Endocrinology & Metabolism
Author(s): Yahya Sohrabi, Rinesh Godfrey, Hannes M. Findeisen
Exposing innate immune cells to an initial insult induces a long-term proinflammatory response due to metabolic and epigenetic alterations which encompass an emerging new concept called trained immunity. Recent studies provide novel insights into mechanisms centered on metabolic reprogramming which induce innate immune memory in hematopoietic stem cells and monocytes.



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